You need to enter some coding to do this. The new damian.css in 1.9 allows modules to have different colours and style by providing some override methods in the modules templates
You will need to create two new CSS elements for left column and right column modules. Then modify the module.tpl to discover if the module is left or right and send the correct CSS tag to the renderer.
An alternative is to remove all font elements from the module CSS styles and drop them into leftcolumn and rightcolumn instead. Depends on how much customisation your looking for.