Have a glance at WebAccessibilityInitiativeDev maybe you could join the team and guide us!
Basically you can design a custom theme to eliminate the left and right column totally, and navigate through a menu similar to tw.o's top bar
All templates are seperate from the PHP code using the Smarty Template engine. so this isnt as bad as it sounds.
If you want more info or guideance on theme designs, please post back!